The disease is most common among Jews of Russian origin. They may also have large ears, a small jaw, brittle nails, and poor hair quality. Affected people have sun-sensitive skin and generally develop a butterfly-shaped band of reddish skin across their nose and cheeks. How tall do people with Bloom syndrome get?īloom syndrome patients are typically shorter and heavier than 97 percent of the population at birth, and they seldom surpass 5 feet tall in maturity. Patients with Bloom syndrome are generally diagnosed before age 20 years therefore, cancers are commonly found early when they can be treated successfully. This suggests that there may be factors in addition to genetics that play a role in cancer development.Ĭancers have been reported in nearly all parts of the body, but especially in the lungs, breast, digestive tract, uterus, ovaries, prostate, skin, central nervous system (brain and spinal cord), lymphatic system, and head and neck region. Also, cancer has been reported in family members of some individuals with Bloom syndrome. However, it has been suggested that genetic defects may be responsible for this condition. The cause of cancer in individuals with Bloom syndrome is not known. These include diabetes, high blood pressure, heart disease, stroke, osteoporosis, and infections (especially pneumonia). People with Bloom syndrome are also at increased risk of other diseases. Other types of cancer that have been reported include: brain tumor, leukemia, lung cancer, stomach cancer. Breast cancer is most common in women with Bloom syndrome. They can get any form of cancer, but the tumors appear earlier in life than in the normal population, and afflicted people frequently have more than one type of cancer. What kind of cancer can you get with Bloom syndrome?īloom syndrome patients are at a higher risk of developing cancer. In fact, one study found that men with Bloom syndrome have a greater risk of developing prostate cancer than do other men who have no family history of the disease. People with Bloom syndrome therefore have an increased risk of developing cancer of the eyes, skin, bladder, bowel, prostate, lung, breast, blood cells, brain, and head/neck. This is because the disease affects DNA repair genes, which are responsible for removing mutations from the genome that would otherwise cause cancer. People with Bloom syndrome are usually very sensitive to sunlight. The disease often becomes apparent when children fail to grow as expected or show other signs of delayed physical development. For example, people with Bloom syndrome may appear normal for their first few years of life but then develop short stature. The onset of symptoms varies depending on which body system is most affected. They also have a higher rate of heart disease and diabetes. People with this disorder are at increased risk of developing cancers of the lungs, breast, ovary, bladder, stomach, intestine, mouth, head and neck. Short height, sun-sensitive skin rashes, and a malfunctioning immune system are all symptoms. Bloom syndrome is a condition that causes sluggish development, UV sensitivity, and an elevated risk of cancer in a variety of bodily systems.
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